Tuberculosis: Revisión Actualizada de Patología, Diagnóstico, Tratamiento y Prevención

Autores/as

  • Pedro Morales Baeza

Palabras clave:

tuberculosis, tratamiento, prevención, epidemiología

Resumen

La tuberculosis (TB) es una enfermedad infecciosa de gran relevancia a nivel global, causante de alta morbilidad y mortalidad, y presenta desafíos tanto en su diagnóstico como en su tratamiento. Este artículo revisa los aspectos claves de la TB, incluyendo su patología, diagnóstico, tratamiento, epidemiología, prevención y las posibles complicaciones que pueden surgir. Se destaca la necesidad de un enfoque multifacético e integrado para combatir eficazmente la TB, considerando tanto aspectos médicos como sociales. Se discuten las nuevas técnicas de diagnóstico y los avances en el tratamiento, pero también se enfatiza la necesidad de mejorar el acceso a estas herramientas en áreas de alta prevalencia. El control y la prevención de la TB sigue siendo un desafío significativo que requiere esfuerzos y compromisos globales sostenidos.

Referencias

World Health Organization. Global tuberculosis report 2023. Geneva: WHO, 2023.

Abubakar I, Pimpin L, Ariti C, Beynon R, Mangtani P, Sterne JA, et al. Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guérin vaccination against tuberculosis. Health Technol Assess. 2013;17(37):1-372, v-vi.

Steingart KR, Henry M, Ng V, Hopewell PC, Ramsay A, Cunningham J, et al. Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis. 2006;6(9):570-81.

Pai M, Denkinger CM, Kik SV, Rangaka MX, Zwerling A, Oxlade O, et al. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. 2014;27(1):3-20.

Boehme CC, Nabeta P, Hillemann D, Nicol MP, Shenai S, Krapp F, et al. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med. 2010;363(11):1005-15.

Nahid P, Dorman SE, Alipanah N, Barry PM, Brozek JL, Cattamanchi A, et al. Official American Thoracic Society/Centers for Disease7. World Health Organization. Latent TB Infection: Updated and consolidated guidelines for programmatic management. Geneva: WHO, 2018.

Centers for Disease Control and Prevention. Tuberculosis (TB) - Risk Factors. Atlanta: CDC, 2020.

O'Garra A, Redford PS, McNab FW, Bloom CI, Wilkinson RJ, Berry MP. The immune response in tuberculosis. Annu Rev Immunol. 2013;31:475-527.

Sharma SK, Mohan A. Tuberculosis: From an incurable scourge to a curable disease - journey over a millennium. Indian J Med Res. 2013;137(3):455-93.

Peto HM, Pratt RH, Harrington TA, LoBue PA, Armstrong LR. Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006. Clin Infect Dis. 2009;49(9):1350-7.

Sharma SK, Mohan A, Sharma A, Mitra DK. Miliary tuberculosis: new insights into an old disease. Lancet Infect Dis. 2005;5(7):415-30.

World Health Organization. Multidrug-resistant tuberculosis (MDR-TB) 2023 Update. Geneva: WHO, 2023.

Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, et al. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir Med. 2017;5(4):291-360.

Pai M, Behr MA, Dowdy D, Dheda K, Divangahi M, Boehme CC, et al. Tuberculosis. Nat Rev Dis Primers. 2016;2:16076.

World Health Organization. Early detection of tuberculosis: An overview of approaches, guidelines and tools. Geneva: WHO, 2011.

Pai M, Denkinger CM, Kik SV, Rangaka MX, Zwerling A, Oxlade O, et al. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. 2014;27(1):3-20.

Zwerling A, Behr MA, Verma A, Brewer TF, Menzies D, Pai M. The BCG World Atlas: a database of global BCG vaccination policies and practices. PLoS Med. 2011;8(3):e1001012.

Steingart KR, Henry M, Ng V, Hopewell PC, Ramsay A, Cunningham J, et al. Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis. 2006;6(9):570-81.

Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, Marais BJ, et al. Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test. Lancet Infect Dis. 2013;13(4):349-61.

Boehme CC, Nabeta P, Hillemann D, Nicol MP, Shenai S, Krapp F, et al. Rapid molecular detection of tuberculosis and rifampin resistance. N Engl J Med. 2010;363(11):1005-15.

Van Dyck P, Vanhoenacker FM, Van den Brande P, De Schepper AM. Imaging of pulmonary tuberculosis. Eur Radiol. 2003;13(8):1771-85.

Bhalla AS, Goyal A, Guleria R, Gupta AK. Chest tuberculosis: radiological review and imaging recommendations. Indian J Radiol Imaging. 2015;25(3):213-25.

World Health Organization. Treatment of Tuberculosis: Guidelines. 4th ed. Geneva: WHO, 2010.

Salifu Yendork J, Kenu E, Bandoh DA. Role of community health workers in improving TB detection on the path to ending TB: a case study in Northern Ghana. BMC Health Serv Res. 2018;18(1):1001.

Naidoo P, Theron G, Rangaka MX, Chihota VN, Vaughan L, Brey ZO, et al. The South African Tuberculosis Care Cascade: Estimated Losses and Methodological Challenges. J Infect Dis. 2017;216(suppl_7):S702-S13.

Karumbi J, Garner P. Directly observed therapy for treating tuberculosis. Cochrane Database Syst Rev. 2015;(5):CD003343.

Pasipanodya JG, McIlleron H, Burger A, Wash PA, Smith P, Gumbo T. Serum drug concentrations predictive of pulmonary tuberculosis outcomes. J Infect Dis. 2013;208(9):1464-73.

World Health Organization. Global tuberculosis report 2022. Geneva: WHO, 2022.

World Health Organization. Tuberculosis. Key facts [Internet]. Geneva: WHO; 2022 [cited 2023 July 10]. Available from: https://www.who.int/news-room/fact-sheets/detail/tuberculosis

Gupta RK, Lucas SB, Fielding KL, Lawn SD. Prevalence of tuberculosis in post-mortem studies of HIV-infected adults and children in resource-limited settings: a systematic review and meta-analysis. AIDS. 2015;29(15):1987-2002.

World Health Organization. WHO policy on collaborative TB/HIV activities: Guidelines for national programmes and other stakeholders. Geneva: WHO, 2012.

Zwerling A, Behr MA, Verma A, Brewer TF, Menzies D, Pai M. The BCG World Atlas: a database of global BCG vaccination policies and practices. PLoS Med. 2011;8(3):e1001012.

Lönnroth K, Jaramillo E, Williams BG, Dye C, Raviglione M. Drivers of tuberculosis epidemics: The role of risk factors and social determinants. Soc Sci Med. 2009;68(12):2240-6.

Akolo C, Adetifa I, Shepperd S, Volmink J. Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev. 2010;(1):CD000171.

Zumla A, Raviglione M, Hafner R, Fordham von Reyn C. Tuberculosis. N Engl J Med. 2013;368(8):745-55.

Allwood BW, Myer L, Bateman ED. A systematic review of the association between pulmonary tuberculosis and the development of chronic airflow obstruction in adults. Respiration. 2013;86(1):76-85.

Nahid P, Dorman SE, Alipanah N, et al. Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis. Clin Infect Dis. 2016;63(7):e147-e95.

Sharma SK, Mohan A. Extrapulmonary tuberculosis. Indian J Med Res. 2004;120(4):316-53.

Pasipanodya JG, McIlleron H, Burger A, Wash PA, Smith P, Gumbo T. Serum drug concentrations predictive of pulmonary tuberculosis outcomes. J Infect Dis. 2013;208(9):1464-73.

World Health Organization. Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response. Geneva: WHO, 2010.

World Health Organization. Global Tuberculosis Report 2023. Geneva: WHO, 2023.

Atun R, Weil DE, Eang MT, Mwakyusa D. Health-system strengthening and tuberculosis control. Lancet. 2010;375(9732):2169-78.

Reid MJ, Arinaminpathy N, Bloom A, Bloom BR, Boehme C, Chaisson R, et al. Building a tuberculosis-free world: The Lancet Commission on tuberculosis. Lancet. 2019;393(10178):1331-84.

Houben RM, Dodd PJ. The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling. PLoS Med. 2016;13(10):e1002152.

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Publicado

2023-07-12

Cómo citar

Tuberculosis: Revisión Actualizada de Patología, Diagnóstico, Tratamiento y Prevención. (2023). Revista Internacional Interdisciplinar De Divulgación Científica, 1(1). https://riidici.com/index.php/home/article/view/18